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As the spread of dengue and dengue haemorrhagic fever is increasing, atypical manifestations are also onthe rise, although they may be under reported because of lack of awareness. This review compiles descriptions of atypical mani...
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As the spread of dengue and dengue haemorrhagic fever is increasing, atypical manifestations are also onthe rise, although they may be under reported because of lack of awareness. This review compiles descriptions of atypical manifestations of dengue, such as dengue encephalitis, dengue myocarditis, dengue hepatitis and dengue cholecystitis.
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BACKGROUND: Dengue fever, an emerging public health issue in Pakistan bears considerable morbidity and mortality. This descriptive cross sectional study was conducted to analyze clinical, hematological and serological characterist...
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BACKGROUND: Dengue fever, an emerging public health issue in Pakistan bears considerable morbidity and mortality. This descriptive cross sectional study was conducted to analyze clinical, hematological and serological characteristics of dengue fever variants and to identify biomarkers that predict its severity. METHODS: 105 dengue cases (>12 years) were selected after ethical approval from Rawal Institute of Health Sciences & Benazir Bhutto Hospital Rawalpindi over 6 months (July to Dec 2015). Patients having pre-existing hematological disorder, liver disease, malaria and typhoid co-infection were excluded. Demographic data, clinical findings, hematological and serological profile documented. Patients were classified as classic dengue fever (DF), dengue hemorrhagic (DHF) and dengue shock syndrome (DSS). Data analyzed via SPSS version 17. RESULTS: Among 105 cases, there were 79(75%) males and 26(25%) females. Mean age was 30 + 12.8 years and mean duration of symptoms 5 + 2 days. Dengue fever was found in 75(75%), dengue hemorrhagic fever 24(23%) and dengue shock syndrome 2(2%). Gender, mean age and duration of symptoms were comparable between DF, DHF and DSS. Common clinical features were fever (100%), headache (56%), muscle pain (43%), vomiting (43%), retro-orbital pain (23%), bleeding (12%) and hypotension (10%). Thrombocytopenia, leukopenia and pancytopenia were frequent in DHF vs. DF. Dengue NS-1 antigen positive in 71(90%) of DF cases vs 16(57%) DHF and 1(50%) DSS. Dengue-IgM positive in 32(47%) DF vs. 19(79%) DHF and 2(100%) DSS. Dengue -IgG detected in 33(42%) DF vs. 17(71%) DHF and 1(50%) DSS. 101(96%) dengue cases were treated successfully and one case expired. CONCLUSION: Dengue-IgG and IgM are better predictive variables for dengue hemorrhagic fever as compared to NS-1 antigen that predicts classic dengue fever. Utilizing these predictive variables, imminent severe dengue may be identified and with vigilant monitoring, fluid resuscitation and pre-hand arrangement of blood products we may reduce complications and mortality in high risk cases.
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A 16-year-old female adolescent presented to the pe-diatric clinic with a history of fever that at times reached 38.3°C (101°F) and general malaise for 2 days after returning from 6 weeks abroad, where she spent time in Banglade...
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A 16-year-old female adolescent presented to the pe-diatric clinic with a history of fever that at times reached 38.3°C (101°F) and general malaise for 2 days after returning from 6 weeks abroad, where she spent time in Bangladesh and Saudi Arabia. Before traveling, the patient and her siblings were seen in the clinic for travel advice, and malaria prophylaxis was prescribed according to Centers for Disease Control and Prevention (CDC) guidelines. The patient disclosed that she did not take the Malarone as prescribed and thought she may have taken only two doses. Nausea and abdominal discomfort prompted her to stop taking the malaria prophylaxis. While traveling, she received multiple mosquito bites, and when visiting a relative's farm in Bangladesh, she played with cows, goats, and ducks. She presented to the clinic with a report of fever, headache, body ache, and an itchy rash on her hands.
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OBJECTIVE :Determine point prevalence of febrile syndromes and compare with prevalence reported by habitual clinical and seroepidemiologic dengue surveillance system in Havana City. METHODS :In October 2007, a descriptive, cross-s...
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OBJECTIVE :Determine point prevalence of febrile syndromes and compare with prevalence reported by habitual clinical and seroepidemiologic dengue surveillance system in Havana City. METHODS :In October 2007, a descriptive, cross-sectional study was carried out in a representative sample, calculating prevalences of febrile syndromes and undifferentiated febrile syndromes. Chi-square analysis was used for rate comparisons. RESULTS :Point prevalences of febrile syndromes and undifferentiated febrile syndromes were 352.6 and 144.2 times greater, respectively, than those reported by the habitual clinical and seroepidemiologic dengue surveillance system; these differences were statistically significant (p < 0.001). CONCLUSIONS :Point prevalence of febrile syndromes was far greater than prevalence reported by the habitual clinical and seroepidemiologic dengue surveillance system, an indication of underreporting.
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Dengue is a very rapidly growing public health problem being currently faced by ∼40% of the global population living in more than a hundred tropical and sub-tropical countries. It is a viral disease, caused by four types of dengu...
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Dengue is a very rapidly growing public health problem being currently faced by ∼40% of the global population living in more than a hundred tropical and sub-tropical countries. It is a viral disease, caused by four types of dengue viruses, transmitted by mosquitoes, to an estimated 50 million people each year. Vector control methods to contain transmission have not been successful and there is currently no useful diagnostic test, drug or vaccine to combat dengue disease. However, as a result of the heightened awareness of its magnitude and its potential to spread beyond the tropical world, dengue has begun to emerge out of the list of neglected diseases in recent years. New interest in this disease has drawn scientists from multiple disciplines into the dengue arena. This has resulted in novel insights into several aspects of dengue virus biology and identified potential drug targets. Several tetravalent vaccines are being developed. Newer animal models that mirror some of the salient features of dengue disease are becoming available to investigate the mechanism of pathogenesis and to aid in drug and vaccine discovery efforts. The realization that therapeutic and prophylactic intervention can be cost-effective has resulted in vigorous industry-driven translational initiatives to develop drugs and vaccines. Dengue research is at a critical juncture and the implementation of existing knowledge supplemented by a better understanding of pathogenesis promises to make a tangible impact in the combat against dengue in the coming years.
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Dengue fever is a tropical disease caused by a virus carried by mosquitoes. The virus can cause fever,headaches, rashes, and pain throughout the body. Most cases of dengue fever are mild and go away on theirown after about a week....
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Dengue fever is a tropical disease caused by a virus carried by mosquitoes. The virus can cause fever,headaches, rashes, and pain throughout the body. Most cases of dengue fever are mild and go away on theirown after about a week. Dengue (DEN-gee) fever is caused by four similar viruses spread by mosquitoes of thegenus Aedes, which are common in tropical and subtropical areas worldwide. When an Aedes mosquito bites aperson who has been infected with a dengue virus, the mosquito can become a carrier of the virus. If thismosquito bites someone else, that person can be infected with dengue fever. The virus can't spread directlyfrom person to person. In rare cases, dengue fever can lead to a more serious form of the disease calleddengue hemorrhagic fever (DHF). DHF can be life threatening and needs to be treated right away.
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Dengue is a mosquito-transmitted infection that poses significant global health risks for travelers and individuals living in the tropics and subtropics. The reported global incidence has increased dramatically in the past century...
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Dengue is a mosquito-transmitted infection that poses significant global health risks for travelers and individuals living in the tropics and subtropics. The reported global incidence has increased dramatically in the past century, with dengue now ranking as the most common cause of febrile illness in travelers. While sporadic cases have been reported within the southern United States since 1980, autochthonous outbreaks have now been described in Hawaii, St. Croix (US Virgin Islands), along the Texas-Mexico border, and, most recently, in Key West, Florida. Although many infections are mild or asymptomatic, 5-10% of patients may experience hemorrhagic disease, with shock and even death. Laboratory identification commonly involves serologic and nucleic acid amplification methods. Due to rising incidence worldwide, physicians should be familiar with the clinical manifestations, laboratory diagnosis, and management of this illness.
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Aim of the study: Dengue infection occurs almost all over subtropical and tropical countries. Dengue pathogenesis explaining its clinical manifestations is still unclear. Indonesia is a country with several hyperendemic regions. T...
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Aim of the study: Dengue infection occurs almost all over subtropical and tropical countries. Dengue pathogenesis explaining its clinical manifestations is still unclear. Indonesia is a country with several hyperendemic regions. The study was aimed to investigate the incidence rate, sero-epidemiology, and the relationship between the serotype and the clinical severity of dengue viral infection in paediatric patients from Gondokusuman, Yogyakarta. Material and methods: It was an epidemiological research with prospective observational design reviewing febrile paediatric patients involved in "A Prospective Sero-epidemiology Study on Dengue Children Infection in Yogyakarta, Indonesia, 1995-1999 cohort study." Febrile paediatric patients were diagnosed for dengue fever, dengue haemorrhagic fever, or dengue shock syndrome based on World Health Organization 1997 criteria. Serological diagnosis was performed using PRNT and serotype identification was performed by viral culture isolation and RT-PCR. Results: Laboratory data (PRNT, ELISA, RT-PCR and Isolation) showed that there were 220 children (130 males and 90 females) from 509 febrile patients among 2149 paediatric subjects who were infected with dengue virus. Based on serotype identification, the following dengue virus serotype distributions were identified: DEN-1 26.81%, DEN-2 23.18%, DEN-3 22.72%, DEN-4 8.63%, and unidentified 18.63%. Clinical severities observed were as follows: dengue fever 78.6%, dengue haemorrhagic fever 18.2%, and dengue shock syndrome 3.2%. In the case of primary infection, only DEN-3 could cause severe clinical manifestations. Conclusions: Gondokusuman region in Yogyakarta could be classified as a hyperendemic region between 1995 and 1999 with the highest risk of severe clinical manifestations shown for DEN-3 during both, primary and secondary infection. ? 2016 Pediatr Med Rodz.
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Background:Liver dysfunction in dengue varies from mild injury with elevation of transaminases to severe hepatocyte injury. Despite hepatocytes are not a major target, hepatic dysfunction is the recurrent feature. Predictive hepat...
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Background:Liver dysfunction in dengue varies from mild injury with elevation of transaminases to severe hepatocyte injury. Despite hepatocytes are not a major target, hepatic dysfunction is the recurrent feature. Predictive hepatic serum markers represent a solution for the dynamic care of serious dengue and predicting disease prognosis. In the present study we pursued to mold the mode of hepatic involvement in children with dengue and its association with seriousness of disease.
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В обзоре на примерах завезенных случаев лихорадки Денге проанализированы основные эпидемиологические и клинические аспекты...
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В обзоре на примерах завезенных случаев лихорадки Денге проанализированы основные эпидемиологические и клинические аспекты болезни. Даны алгоритмы обследования больных с лихорадкой неясной этиологии, прибывших из тропических стран. На основании обширных данных литературы и международных рекомендаций представлены алгоритмы тактики лечения амбулаторных и стационарных больных лихорадкой Денге. Проанализированы перспективные исследования вакцинопрофилактики лихорадки Денге.
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